Mayo Chiki!'s main protagonist, Sakamachi Kinjirou, has the worst case of gynophobia known to man. Just one touch from a girl and his nose bleeds almost uncontrollably. His condition is all thanks to his family of female wrestlers who "trained" him a bit too much as a child. Through this tough love, Kinjirou developed a body able to withstand hard blows... as well as an intense fear of the female race. Life with such a handicap is difficult in itself, but after one ominous visit to the school restroom, Kinjirou's semi-peaceful existence shifts into complete chaos. He discovers that the suave Subaru-sama, the bodyguard to the headmaster's daughter Kanade, is actually a girl. In exchange for his silence in the matter, Kanade promises to help him overcome his gynophobia.
A cross dressing butler, a high-class twisted beauty, a BL writer wannabe, an aspiring pro-wrestler, and someone who lives with ghosts―these are the kind of girls that Sakamachi Kinjirou must deal with everyday. With such a unique cast of characters, high school life in Mayo Chiki! is sure to bring about a ton of wacky adventures.