Mikoto Uchiha was the mother of Sasuke and Itachi. She was also Fugaku's wife. While she was alive, she seemed to like Sasuke better where her husband seemed to prefer Itachi. She was a very good mother, seeing as how Sasuke was able to talk to her better than his father. At one point, in order to cheer Sasuke up, she says that when she and Fugaku are alone Sasuke is all he talks about. Although she was Itachi's mother, she did have some suspicion about Itachi and knew that something was up. She was found dead with her husband during the Uchiha Clan Massacre, killed by Itachi.