Fuse were hybrid creatures of humans and dogs in the Edo period. As there were rumors saying that they killed humans and ate their souls, the Shogun Government offered high bounty for hunting them.

Hamaji was a young female huntress living in the rural part of Mutsu while her brother Dousetsu was living in Edo. The story began as Hamaji went to Edo in order to help his brother to earn some bounty. But in Edo, she met a mysterious young men being chased by others. His name was Shino...

(Source: partially translated from Wikipedia JP)