TWO-MIX is a Japanese pop group formed in 1995. The members are Minami Takayama (vocals and composer) and Shiina Nagano (synthezier and lyricist). Their music-style is fast electronic pop.

They met in the early 1990s. Takayama, already well-established as a voice actress, was in the indie band RE-X and met Nagano through a friend. Takayama released a solo album in 1992, Endless Communication which Nagano contributed to. They formed a group together Es Connexion and released in an album. In 1995 they formed TWO-MIX.

They have been featured in various anime such as Gundam Wing or Meitantei Conan (in which the titular character, Conan Edogawa, is voiced by Takayama; they also made a guest appearance in one of the episode in which they were kidnapped and saved by Conan and his friends).